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PUBLICATIONS

Featured research

Full list of published papers

Members of the lab are highlighted!

FOCUSED BRAIN INTERVENTIONS

A full list of publications to date can be found here.

  1. Ioannou Z, Cressey P, Ahmed M H, Pouliopoulos A N, Hargrave D, Thanou M (2026). STING agonism in brain tumours: mechanisms, challenges, and therapeutic advances. Frontiers in Oncology, 16, 1679361.​

  2. Nabavizadeh A, Narsinh K, Kaufmann T J, Liu H, Pouliopoulos A N, Prada F, Agarwal V, Ellingson B M, Sanvito F, Everson R G, Meng Y, Gandhi D, Chang S M, Wen P Y, Ahluwalia M S, Sul N, Hadley L, Leblang S, Shah B R, Arvanitis C D, Burns T C, Moosa S, Woodworth G F (2025). Focused Ultrasound in Brain Tumors: Mechanisms, Imaging Guidance, and Emerging Clinical Applications. American Journal of Neuroradiology, ajnr.A 9126.

  3. Pouliopoulos A N (2025). Focused ultrasound treatments could increase survival in individuals with glioma. The Lancet Oncology, 26, 12, 1522–1524.

  4. Wu C-C, Szalontay L, Pouliopoulos A N, Bae S, Berg X, Wei H-J, Webster Carrion A, Kokossis D, Sethi C, Fino J, Shatravka H, Lipina J, Ji R, Liu K, Yousefian O, Gallitto M, Yoh N, Englander Z, McQuillan N,Tazhibi M, De Los Santos G, Canoll P, Jin Z, Garvin J, Gartrell R, Pavisic J, Maddocks A, Lignelli A, Feldstein N, Konofagou E E, Zacharoulis S (2025). Blood-brain barrier opening with neuronavigation-guided focused ultrasound in pediatric patients with diffuse midline glioma. Science Translational Medicine, 17, 6645.

  5. Burstow R & Pouliopoulos A N (2025). Evaluating the accuracy of acoustic holograms for precise spatial targeting within the brain. npj Acoustics 2025 1, 1, 1–9

  6. Mishra A, Payne C, Carrascal-Miniño A, Sunassee K, Halbherr S, de Rosales R T M†, Pouliopoulos A N† (2025). PET imaging for non-invasive monitoring of 89Zr-Talidox delivery to the brain following focused ultrasound-mediated blood-brain barrier opening. Journal of Controlled Release, 387, 114183. †: Equal contribution.

  7. Gomes L, Pardo-Pastor C, Rosenblatt J, Pouliopoulos A N (2025). Mechanotransduction as a therapeutic target for brain tumours. EBioMedicine, 117, 105808.

  8. Mekki Y M, Rhim H C, Daneshvar D, Pouliopoulos A N, Curtin C, Hagert E (2025). Applications of artificial intelligence in ultrasound imaging for carpal-tunnel syndrome diagnosis: a scoping review. International Orthopaedics, 1–9.

  9. Koruk H, Payne C, Cressey P, Thanou M, Pouliopoulos A N (2025). Delivering Gd-labelled IgG antibodies into the mouse brain following focused ultrasound treatment Ultrasound in Medicine & Biology, 51, 6.

  10. Burstow R, Andrés D, Jiménez N, Camarena F, Thanou M, & Pouliopoulos A N (2025). Acoustic holography in biomedical applications. Physics in Medicine & Biology, 70, 6, 06TR01.

  11. Payne C, Cressey P, Talianu A, Szychot E, Hargrave D, Thanou M, Pouliopoulos A N (2024). Bi-modal confirmation of liposome delivery to the brain after focused ultrasound-induced blood-brain barrier opening. Heliyon, 10, 22, e39972.

  12. Zhu H, Allwin C, Bassous M G, Pouliopoulos A N (2024). Focused Ultrasound-Mediated Enhancement of Blood-Brain Barrier Permeability for Brain Tumor Treatment - A Systematic Review of Clinical Trials (2024). Journal of Neuro-Oncology, 170, 235–252.

  13. Pouliopoulos A N†, Bae S†, Liu K†, Ji R, Jimenez-Gambin S, Yousefian O, Murillo M F, Kokossis D, Honig L S, Konofagou E E (2024). Transcranial Blood–Brain Barrier Opening in Alzheimer’s Disease Patients Using A Portable Focused Ultrasound System with Real-Time 2-D Cavitation Mapping. Theranostics 14, 11, 4519–4535. †: Equal contribution.

  14. Koruk H & Pouliopoulos A N (2023). Elasticity and Viscoelasticity Imaging Based on Small Particles Exposed to External Forces. Processes, 11, 12, 3402.

  15. Koruk H & Pouliopoulos A N (2023). Investigation of the Motion of a Spherical Object Located at Soft Elastic and Viscoelastic Material Interface for Identification of Material Properties. Applied Science and Engineering Progress, 17, 4, 7277.

  16. Koruk H, Koc H O, Yurdaer S B, Besli A, Pouliopoulos A N (2023). A New Approach for Measuring Viscoelastic Properties of Soft Materials Using the Dynamic Response of a Spherical Object Placed at the Sample Interface. Experimental Mechanics 64, 1, 21–32.

  17. Liu D, Munoz F, Sanatkhani S, Pouliopoulos A N, Konofagou E E, Grinband J, & Ferrera V P (2023). Alteration of functional connectivity in the cortex and major brain networks of non-human primates following focused ultrasound exposure in the dorsal striatum. Brain Stimulation 16, 4, 1196–1204.

  18. Karakatsani M E, Ji R, Murillo M F, Kugelman T, Kwon N, Lao Y-H, Liu K, Pouliopoulos A N, Honig L S, Duff K E, & Konofagou E E (2023). Focused ultrasound mitigates pathology and improves spatial memory in Alzheimer’s mice and patients. Theranostics 13, 12, 4102–4120.

  19. Zhang W, Metzger H, Vlatakis S, Claxton A, Alejandra Carbajal M, Fan Fung L, Mason J, Andrew Chan K L, Pouliopoulos A N, Prentice P, Fleck R A, Thanou M (2023). Characterising the chemical and physical properties of phase-change nanodroplets. Ultrasonics Sonochemistry, 106445

  20. Bae S, Liu K, Pouliopoulos A N, Ji R, Konofagou E E (2023). Real-Time Passive Acoustic Mapping With Enhanced Spatial Resolution in Neuronavigation-Guided Focused Ultrasound for Blood–Brain Barrier Opening. IEEE Transactions on Biomedical Engineering, 1–12

  21. Pouliopoulos A N (2023). Evaluating drug delivery enhancement following ultrasound treatment. The Lancet Oncology, 24, 5, 420–422.

  22. Noel R L, Batts A J, Ji R, Pouliopoulos A N, Bae S, Kline-Schoder A R, Konofagou E E (2023). Natural aging and Alzheimer’s disease pathology increase susceptibility to focused ultrasound-induced blood–brain barrier opening. Scientific Reports 13:1, 1–13.

  23. Aurup C, Pouliopoulos A N, Kwon N, Murillo M F, Konofagou E E (2023). Evaluation of Non-invasive Optogenetic Stimulation with Transcranial Functional Ultrasound Imaging. Ultrasound in Medicine & Biology 49, 3, 908–917.

  24. Pouliopoulos A N, Murillo M F, Noel R L, Batts A, Ji R, Kwon N, Yu H, Tong C-K, Gelinas J N, Khodagholy Araghy D, S Hussaini S A, Konofagou E E (2022). Non-invasive optogenetics with ultrasound-mediated gene delivery and red-light excitation. Brain Stimulation 15, 4, 927-941.

  25. Munoz F, Meaney A, Gross A S, Liu K, Pouliopoulos A N, Konofagou E E, Ferrera V P (2022). Long Term Study of Motivational and Cognitive Effects of Low-intensity Focused Ultrasound Neuromodulation in the Dorsal Striatum of Nonhuman Primates. Brain Stimulation, 15, 2, 360-372.

  26. Jimenez-Gambin S, Jimenez N, Pouliopoulos A N, Benlloch J M, Konofagou E E, Camanera F (2022). Acoustic holograms for bilateral blood-brain barrier in a mouse model. IEEE Trans. Biomed. Engineering 69, 4, 1359-1368.

  27. Pouliopoulos A N, Kwon N, Jensen G, Meaney A, Niimi Y, Burgess M T, McLuckie A J, Munoz F, Ji R, Kamimura H A S, Teich A F, Ferrera V P, Konofagou E E (2021). Safety evaluation of a clinical focused ultrasound system for neuronavigation guided blood-brain barrier opening in non-human primates. Scientific Reports 11 15043. 

  28. Pouliopoulos A N†, Karakatsani M E†, Liu M, Jambawalikar S, Konofagou E E (2021). Contrast-free detection of focused-ultrasound-induced blood-brain barrier opening by diffusion tensor imaging. IEEE Trans. Biomed. Engineering 68, 8, 2499-2508. †Equal contribution.

  29. Wei H-J, Upadhyayula P S, Pouliopoulos A N, Englander Z K, Zhang X, Jan C-I, Guo J, Mela A, Zhang Z, Wang T J C, Bruce J N, Canoll P D, Feldstein N A, Zacharoulis S, Konofagou E E, Wu C-C (2021) Focused ultrasound-mediated blood brain barrier opening increases delivery and efficacy of etoposide for glioblastoma treatment. Int. Journal of Radiation Oncology, Biology, Physics 100 539-550.

  30. Englander Z K, Wei H-J, Pouliopoulos A N, Bendau E, Upadhyayula P, Spinazzi E F, Jan C-I, Wang T J C, Canoll P, Bruce J N, Feldstein N A, Zacharoulis S, Konofagou E E, Wu C-C (2021). Focused Ultrasound Mediated Blood Brain Barrier Opening in a Murine Pontine Glioma Model: A Safety and Feasibility Study. Scientific Reports 11 6521.

  31. Kamimura H A S, Wu S Y, Grondin J, Ji R, Aurup C, Zheng W, Pouliopoulos A N, Konofagou E E (2021). Real-time passive acoustic mapping using sparse matrix vector multiplication. IEEE Trans. Ultrason. Ferroelectr. Freq. Control 68 164-177.

  32. Pouliopoulos A N, Smith C A B, Bezer J, El Ghamrawy A, Sujarittam K, Bouldin C J, Morse S V, Tang M X, Choi J J (2020). Doppler Passive Acoustic Mapping. IEEE Trans. Ultrason. Ferroelectr. Freq. Control  67 2692–2703.

  33. Galan-Acosta L, Sierra C, Leppert, A, Pouliopoulos A N, Noel R L, Kwon N, Tambaro S, Presto J, Nilsson P, Konofagou E E, Johansson, J (2020). Recombinant BRICHOS chaperone domains delivered to mouse brain parenchyma by focused ultrasound and microbubbles get internalized by hippocampal and cortical neurons. Molecular and Cellular Neuroscience 105 103498.

  34. Pouliopoulos A N, Jimenez D A, Frank A, Robertson A, Zhang L, Klein-Schoder A R, Bhaskar V, Harpale M, Caso E, Papapanou N, Anderson R, Li R, Konofagou E E (2020). Temporal stability of lipid-shelled microbubbles during acoustically-mediated blood-brain barrier opening. Frontiers in Physics 137 8.

  35. Morse S V, Boltersdorf T, Harriss B I, Chan T G, Baxan N, Jung H S, Pouliopoulos A N, Choi J J, Long N J (2020). Neuron labelling with rhodamine-conjugated Gd-based MRI contrast agents delivered to the brain with focused ultrasound. Theranostics 10 2659-2674.

  36. Pouliopoulos A N, Wu S Y, Burgess M T, Karakatsani M E, Kamimura H A S, Konofagou E E (2020). A clinical ultrasound system for non-invasive blood-brain barrier opening using a neuronavigation-guided single-element transducer. Ultrasound in Medicine & Biology 46 73-89.

  37. Morse S V, Pouliopoulos A N, Chan T G, Copping M J, Lin J, Long N J, Choi J J (2019). Rapid short pulse ultrasound delivers drugs uniformly across the murine blood-brain barrier with negligible disruption. Radiology 291 181625.

  38. Pouliopoulos A N, Burgess M T, Konofagou E E (2018). Pulse inversion enhances the passive mapping of microbubble-mediated ultrasound therapy. Appl. Phys. Lett. 113 044102-6.

  39. Lazarus C, Pouliopoulos A N, Tinguely M, Garbin V and Choi J J (2017). Clustering dynamics of microbubbles exposed to low-pressure 1-MHz ultrasound. J. Acoust. Soc. Am. 142 3135–46.

  40. Heymans S V, Martindale C F, Suler A, Pouliopoulos A N, Dickinson R J and Choi J J (2017). Simultaneous Ultrasound Therapy and Monitoring of Microbubble-Seeded Acoustic Cavitation Using a Single-Element Transducer. IEEE Trans. Ultrason. Ferroelectr. Freq. Control 64 1234–44.

  41. Pouliopoulos A N, Li C, Tinguely M, Garbin V, Tang M-X and Choi J J (2016). Rapid short-pulse sequences enhance the spatiotemporal uniformity of acoustically driven microbubble activity during flow conditions. J. Acoust. Soc. Am. 140 2469–80.

  42. Pouliopoulos A N and Choi J J (2016). Superharmonic microbubble Doppler effect in ultrasound therapy. Phys. Med. Biol. 61 6154–71.

  43. Koruk H, El Ghamrawy A, Pouliopoulos A N and Choi J J (2015). Acoustic Particle Palpation for Measuring Tissue Elasticity. Appl. Phys. Lett. 107 223701–4.

  44. Shamout F E, Pouliopoulos A N, Lee P, Bonaccorsi S, Towhidi L, Krams R and Choi J J (2015). Enhancement of non-invasive trans-membrane drug delivery using ultrasound and microbubbles during physiologically relevant flow. Ultrasound Med. Biol. 41 2435–48.

  45. Pouliopoulos A N, Bonaccorsi S and Choi J J (2014). Exploiting flow to control the in vitro spatiotemporal distribution of microbubble-seeded acoustic cavitation activity in ultrasound therapy. Phys. Med. Biol. 59 6941–57.

  46. Niu G, Zoellner M H, Zaumseil P, Pouliopoulos A N, d’Acapito F, Schroeder T and Boscherini F (2013). X-ray diffraction and extended X-ray absorption fine structure study of epitaxial mixed ternary bixbyite PrxY2−xO3 (x = 0–2) films on Si (111) J. Appl. Phys. 113 043504.

SUPER-RESOLUTION ULTRASOUND IMAGING

A full list of publications to date can be found here.

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ULTRASOUND FOR IMAGING & MATERIAL CHARACTERISATION

A full list of publications to date can be found here. ​​

  1. ​Lian, W., Baker, C., Rostami, J., West, S., Diamantopoulos, A., Ourselin, S., Peralta, L., & Xia, W. (2026).  Multilateration-based needle tracking with 3D ultrasound imaging for guiding minimally invasive procedures. Physics in Medicine & Biology, 71(7), 075018.

  2. Dryburgh, P., Hajnal, J. V., & Peralta, L. (2026). Coherent multi-transducer ultrasound imaging using diverging wave. Ultrasonics, 108028.

  3. Lian, W., Rostami, J., Baker, C., West, S., Diamantopoulos, A., Mathews, S., Desjardins, A. E., Ourselin, S., Peralta, L., & Xia, W. (2026). Volumetric Ultrasound Imaging With a Sparse Matrix Array and Integrated Fiber-Optic Sensing for Robust Needle Tracking in Interventional Procedures. IEEE Sensors Journal, 26(6), 8915-8922.

  4. Dryburgh, P., Mazierli, D., Hajnal, J. V., Tortoli, P., Ramalli, A., & Peralta, L. (2025). Specific Filtered Delay Multiply and Sum beamforming for coherent multi-transducer ultrasound imaging. Ultrasonics, 107731.​

  5. Peralta, L. & Christensen-Jeffries, K. (2025). Effects of Aberration on Super-Resolution Ultrasound Imaging using Microbubbles. A Simulation study. IEEE Access, 13, 178034-178044.

  6. Mazierli, D., Tortoli, P., Peralta, L., & Ramalli, A. (2025). Multi-probe Vector Velocity Estimation in Deep and Large Regions of Interest: a Simulation Study. IEEE Transactions on Biomedical Engineering.

  7. Raad, J. P., Lock, D., Liu, Y. Y., Solomon, M., Peralta, L., & Christensen-Jeffries, K. (2024). Optically validated microvascular phantom for super-resolution ultrasound imaging. IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control, 71(12: Breaking the Resolution Barrier in Ultrasound), 1833-1843.

  8. Amadou, A. A., Peralta, L., Dryburgh, P., Klein, P., Petkov, K., Housden, R. J., ... & Rhode, K. (2024). Cardiac ultrasound simulation for autonomous ultrasound navigation. Frontiers in Cardiovascular Medicine, 11, 1384421.

  9. Sultan, H. H., Grisan, E., Dryburgh, P., Peralta, L., & Harput, S. (2024). A consensus mechanism to improve prediction of cortical bone properties using ultrafast ultrasound acquisition. IEEE Access, 12, 78148-78160.

  10. Peralta, L., Mazierli, D., Christensen-Jeffries, K., Ramalli, A., Tortoli, P., & Hajnal, J. V. (2023). On the arrays distribution, scan sequence and apodization in coherent dual-array ultrasound imaging systems. Applied Sciences, 13(19), 10924.

  11. Peralta, L., Mazierli, D., Gomez, A., Hajnal, J. V., Tortoli, P., & Ramalli, A. (2023). 3-D coherent multi transducer ultrasound imaging with sparse spiral arrays. IEEE transactions on ultrasonics, ferroelectrics, and frequency control, 70(3), 197-206.

  12. Peralta, L., Redin, J. D. M., Fan, F., Cai, X., Laugier, P., Schneider, J., ... & Grimal, Q. (2021). Bulk wave velocities in cortical bone reflect porosity and compression strength. Ultrasound in Medicine & Biology, 47(3), 799-808.

  13. Peralta, L., Ramalli, A., Reinwald, M., Eckersley, R. J., & Hajnal, J. V. (2020). Impact of aperture, depth, and acoustic clutter on the performance of coherent multi-transducer ultrasound imaging. Applied Sciences, 10(21), 7655.​

  14. Iori, G., Schneider, J., Reisinger, A., Heyer, F., Peralta, L., Wyers, C., ... & Raum, K. (2020). Cortical thinning and accumulation of large cortical pores in the tibia reflect local structural deterioration of the femoral neck. Bone, 137, 115446.

  15. Cai, X., Peralta, L., Brenner, R., Iori, G., Cassereau, D., Raum, K., ... & Grimal, Q. (2020). Anisotropic elastic properties of human cortical bone tissue inferred from inverse homogenization and resonant ultrasound spectroscopy. Materialia, 11, 100730.

  16. Iori, G., Peralta, L., Reisinger, A., Heyer, F., Wyers, C., van den Bergh, J., ... & Raum, K. (2020). Femur strength predictions by nonlinear homogenized voxel finite element models reflect the microarchitecture of the femoral neck. Medical Engineering & Physics, 79(1), 60-66.

  17. Peralta, L., Gomez, A., Luan, Y., Kim, B. H., Hajnal, J. V., & Eckersley, R. J. (2019). Coherent multi-transducer ultrasound imaging. IEEE transactions on ultrasonics, ferroelectrics, and frequency control, 66(8), 1316-1330.​

  18. Boughton, O. R., Ma, S., Cai, X., Yan, L., Peralta, L., Laugier, P., ... & Cobb, J. P. (2019). Computed tomography porosity and spherical indentation for determining cortical bone millimetre-scale mechanical properties. Scientific reports, 9(1), 7416.

  19. Cai, X., Follet, H., Peralta, L., Gardegaront, M., Farlay, D., Gauthier, R., ... & Laugier, P. (2019). Anisotropic elastic properties of human femoral cortical bone and relationships with composition and microstructure in elderly. Acta Biomaterialia, 90, 254-266.

  20. Iori, G., Schneider, J., Reisinger, A., Heyer, F., Peralta, L., Wyers, C., ... & Raum, K. (2019). Large cortical bone pores in the tibia are associated with proximal femur strength. PLoS One, 14(4), e0215405.

  21. Peralta, L., Gomez, A., Hajnal, J. V., & Eckersley, R. J. (2019, March). Coherent multi-transducer ultrasound imaging in the presence of aberration. In Medical Imaging 2019: Ultrasonic Imaging and Tomography (Vol. 10955, pp. 152-161). SPIE.

  22. Melchor, J., Parnell, W. J., Bochud, N., Peralta, L., & Rus, G. (2019). Damage prediction via nonlinear ultrasound: A micro-mechanical approach. Ultrasonics, 93, 145-155.

  23. Cai, X., Brenner, R., Peralta, L., Olivier, C., Gouttenoire, P. J., Chappard, C., ... & Grimal, Q. (2019). Homogenization of cortical bone reveals that the organization and shape of pores marginally affect elasticity. Journal of the Royal Society Interface, 16(151), 20180911.

  24. Cai, X., Peralta, L., Gouttenoire, P. J., Olivier, C., Peyrin, F., Laugier, P., & Grimal, Q. (2017). Quantification of stiffness measurement errors in resonant ultrasound spectroscopy of human cortical bone. The Journal of the Acoustical Society of America, 142(5), 2755-2765.

  25. Peralta, L., Cai, X., Laugier, P., & Grimal, Q. (2017). A critical assessment of the in-vitro measurement of cortical bone stiffness with ultrasound. Ultrasonics, 80, 119-126.

  26. Cai, X., Peralta, L., Giron, A., Helfen, L., Olivier, C., Peyrin, F., ... & Grimal, Q. (2017). Cortical bone elasticity measured by resonant ultrasound spectroscopy is not altered by defatting and synchrotron X-ray imaging. Journal of the mechanical behavior of biomedical materials, 72, 241-245.

  27. Peralta, L., Molina, F. S., Melchor, J., Gómez, L. F., Massó, P., Florido, J., & Rus, G. (2017). Transient elastography to assess the cervical ripening during pregnancy: a preliminary study. Ultraschall in der Medizin-European Journal of Ultrasound, 38(04), 395-402.

  28. Peralta, L., Mourier, E., Richard, C., Charpigny, G., Larcher, T., Aït-Belkacem, D., ... & Chavatte-Palmer, P. (2015). In vivo evaluation of cervical stiffness evolution during induced ripening using shear wave elastography, histology and 2 photon excitation microscopy: insight from an animal model. PloS one, 10(8), e0133377.

  29. Peralta, L., Rus, G., Bochud, N., & Molina, F. S. (2015). Mechanical assessment of cervical remodelling in pregnancy: insight from a synthetic model. Journal of Biomechanics, 48(9), 1557-1565.

  30. Peralta, L., Rus, G., Bochud, N., & Molina, F. S. (2015). Assessing viscoelasticity of shear wave propagation in cervical tissue by multiscale computational simulation. Journal of biomechanics, 48(9), 1549-1556.

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