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PUBLICATIONS

Published Papers

Members of the lab are highlighted!

FOCUSED BRAIN INTERVENTIONS

A full list of publications to date can be found here.

  1. Zhang W, Metzger H, Vlatakis S, Claxton A, Alejandra Carbajal M, Fan Fung L, Mason J, Andrew Chan K L, Pouliopoulos A N, Prentice P, Fleck R A, Thanou M 2023 Characterising the chemical and physical properties of phase-change nanodroplets. Ultrasonics Sonochemistry, 106445

  2. Bae S, Liu K, Pouliopoulos A N, Ji R, Konofagou E E 2023 Real-Time Passive Acoustic Mapping With Enhanced Spatial Resolution in Neuronavigation-Guided Focused Ultrasound for Blood–Brain Barrier Opening. IEEE Transactions on Biomedical Engineering, 1–12

  3. Pouliopoulos A N 2023 Evaluating drug delivery enhancement following ultrasound treatment. The Lancet Oncology, 24, 5, 420–422.

  4. Noel R L, Batts A J, Ji R, Pouliopoulos A N, Bae S, Kline-Schoder A R, Konofagou E E 2023 Natural aging and Alzheimer’s disease pathology increase susceptibility to focused ultrasound-induced blood–brain barrier opening. Scientific Reports 13:1, 1–13.

  5. Aurup C, Pouliopoulos A N, Kwon N, Murillo M F, Konofagou E E 2023 Evaluation of Non-invasive Optogenetic Stimulation with Transcranial Functional Ultrasound Imaging. Ultrasound in Medicine & Biology 49, 3, 908–917.

  6. Pouliopoulos A N, Murillo M F, Noel R L, Batts A, Ji R, Kwon N, Yu H, Tong C-K, Gelinas J N, Khodagholy Araghy D, S Hussaini S A, Konofagou E E 2022 Non-invasive optogenetics with ultrasound-mediated gene delivery and red-light excitation. Brain Stimulation 15, 4, 927-941.

  7. Munoz F, Meaney A, Gross A S, Liu K, Pouliopoulos A N, Konofagou E E, Ferrera V P 2022 Long Term Study of Motivational and Cognitive Effects of Low-intensity Focused Ultrasound Neuromodulation in the Dorsal Striatum of Nonhuman Primates. Brain Stimulation, 15, 2, 360-372.

  8. Jimenez-Gambin S, Jimenez N, Pouliopoulos A N, Benlloch J M, Konofagou E E, Camanera F 2022 Acoustic holograms for bilateral blood-brain barrier in a mouse model. IEEE Trans. Biomed. Engineering 69, 4, 1359-1368.

  9. Pouliopoulos A N, Kwon N, Jensen G, Meaney A, Niimi Y, Burgess M T, McLuckie A J, Munoz F, Ji R, Kamimura H A S, Teich A F, Ferrera V P, Konofagou E E 2021 Safety evaluation of a clinical focused ultrasound system for neuronavigation guided blood-brain barrier opening in non-human primates. Scientific Reports 11 15043. 

  10. Pouliopoulos A N†, Karakatsani M E†, Liu M, Jambawalikar S, Konofagou E E 2021 Contrast-free detection of focused-ultrasound-induced blood-brain barrier opening by diffusion tensor imaging. IEEE Trans. Biomed. Engineering 68, 8, 2499-2508. †Equal contribution.

  11. Wei H-J, Upadhyayula P S, Pouliopoulos A N, Englander Z K, Zhang X, Jan C-I, Guo J, Mela A, Zhang Z, Wang T J C, Bruce J N, Canoll P D, Feldstein N A, Zacharoulis S, Konofagou E E, Wu C-C 2021 Focused ultrasound-mediated blood brain barrier opening increases delivery and efficacy of etoposide for glioblastoma treatment. Int. Journal of Radiation Oncology, Biology, Physics 100 539-550.

  12. Englander Z K, Wei H-J, Pouliopoulos A N, Bendau E, Upadhyayula P, Spinazzi E F, Jan C-I, Wang T J C, Canoll P, Bruce J N, Feldstein N A, Zacharoulis S, Konofagou E E, Wu C-C 2021 Focused Ultrasound Mediated Blood Brain Barrier Opening in a Murine Pontine Glioma Model: A Safety and Feasibility Study. Scientific Reports 11 6521.

  13. Kamimura H A S, Wu S Y, Grondin J, Ji R, Aurup C, Zheng W, Pouliopoulos A N, Konofagou E E 2021 Real-time passive acoustic mapping using sparse matrix vector multiplication. IEEE Trans. Ultrason. Ferroelectr. Freq. Control 68 164-177.

  14. Pouliopoulos A N, Smith C A B, Bezer J, El Ghamrawy A, Sujarittam K, Bouldin C J, Morse S V, Tang M X, Choi J J 2020 Doppler Passive Acoustic Mapping. IEEE Trans. Ultrason. Ferroelectr. Freq. Control  67 2692–2703.

  15. Galan-Acosta L, Sierra C, Leppert, A, Pouliopoulos A N, Noel R L, Kwon N, Tambaro S, Presto J, Nilsson P, Konofagou E E, Johansson, J 2020 Recombinant BRICHOS chaperone domains delivered to mouse brain parenchyma by focused ultrasound and microbubbles get internalized by hippocampal and cortical neurons. Molecular and Cellular Neuroscience 105 103498.

  16. Pouliopoulos A N, Jimenez D A, Frank A, Robertson A, Zhang L, Klein-Schoder A R, Bhaskar V, Harpale M, Caso E, Papapanou N, Anderson R, Li R, Konofagou E E 2020 Temporal stability of lipid-shelled microbubbles during acoustically-mediated blood-brain barrier opening. Frontiers in Physics 137 8.

  17. Morse S V, Boltersdorf T, Harriss B I, Chan T G, Baxan N, Jung H S, Pouliopoulos A N, Choi J J, Long N J 2020 Neuron labelling with rhodamine-conjugated Gd-based MRI contrast agents delivered to the brain with focused ultrasound. Theranostics 10 2659-2674.

  18. Pouliopoulos A N, Wu S Y, Burgess M T, Karakatsani M E, Kamimura H A S, Konofagou E E 2020 A clinical ultrasound system for non-invasive blood-brain barrier opening using a neuronavigation-guided single-element transducer. Ultrasound in Medicine and Biology 46 73-89.

  19. Morse S V, Pouliopoulos A N, Chan T G, Copping M J, Lin J, Long N J, Choi J J 2019 Rapid short pulse ultrasound delivers drugs uniformly across the murine blood-brain barrier with negligible disruption. Radiology 291 181625.

  20. Pouliopoulos A N, Burgess M T, Konofagou E E 2018 Pulse inversion enhances the passive mapping of microbubble-mediated ultrasound therapy. Appl. Phys. Lett. 113 044102-6.

  21. Lazarus C, Pouliopoulos A N, Tinguely M, Garbin V and Choi J J 2017 Clustering dynamics of microbubbles exposed to low-pressure 1-MHz ultrasound. J. Acoust. Soc. Am. 142 3135–46.

  22. Heymans S V, Martindale C F, Suler A, Pouliopoulos A N, Dickinson R J and Choi J J 2017 Simultaneous Ultrasound Therapy and Monitoring of Microbubble-Seeded Acoustic Cavitation Using a Single-Element Transducer. IEEE Trans. Ultrason. Ferroelectr. Freq. Control 64 1234–44.

  23. Pouliopoulos A N, Li C, Tinguely M, Garbin V, Tang M-X and Choi J J 2016 Rapid short-pulse sequences enhance the spatiotemporal uniformity of acoustically driven microbubble activity during flow conditions. J. Acoust. Soc. Am. 140 2469–80.

  24. Pouliopoulos A N and Choi J J 2016 Superharmonic microbubble Doppler effect in ultrasound therapy. Phys. Med. Biol. 61 6154–71.

  25. Koruk H, El Ghamrawy A, Pouliopoulos A N and Choi J J 2015 Acoustic Particle Palpation for Measuring Tissue Elasticity. Appl. Phys. Lett. 107 223701–4.

  26. Shamout F E, Pouliopoulos A N, Lee P, Bonaccorsi S, Towhidi L, Krams R and Choi J J 2015 Enhancement of non-invasive trans-membrane drug delivery using ultrasound and microbubbles during physiologically relevant flow. Ultrasound Med. Biol. 41 2435–48.

  27. Pouliopoulos A N, Bonaccorsi S and Choi J J 2014 Exploiting flow to control the in vitro spatiotemporal distribution of microbubble-seeded acoustic cavitation activity in ultrasound therapy. Phys. Med. Biol. 59 6941–57.

  28. Niu G, Zoellner M H, Zaumseil P, Pouliopoulos A N, d’Acapito F, Schroeder T and Boscherini F 2013 X-ray diffraction and extended X-ray absorption fine structure study of epitaxial mixed ternary bixbyite PrxY2−xO3 (x = 0–2) films on Si (111) J. Appl. Phys. 113 043504.

SUPER-RESOLUTION ULTRASOUND IMAGING

A full list of publications to date can be found here.

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ULTRASOUND FOR IMAGING & MATERIAL CHARACTERISATION

A full list of publications to date can be found here.

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